LC-MS analysis

High-Throughput Screening and Quantification of Small Molecules

BioXpedia Offers

LC-MS

BioXpedia offers Liquid Chromatography Mass Spectrometry (LC-MS) for analyses of small molecule drugs and their metabolites. LC-MS is a powerful tool for PK-PD and toxicity studies, analyzing both pharmaceutical products and raw materials. We develop and validate test methods for novel compounds to meet specific customer needs.

 

Technologies for LC-MS:

The Sciex QTRAP 4500 combines the physical separation of high-pressure liquid chromatography (HPLC) with a mass spectrometer for detection with high compound selectivity. This provides a very sensitive analysis, detecting small molecules with a weight of 5-2000 Da.

 

Sample Types for LC-MS

LC-MS can be used on different matrices like plasma and dialysate but can also be applied to many other biological materials. Our lab can help in preparing samples, which requires both good extraction methods and extensive clean-up of interfering substances. Methods required will depend on the analyte of interest.

Examples of sample types:

  • Plasma
  • Serum
  • Whole blood
  • Dialysate
  • Urine
  • Cell culture medium
  • Tissue

Please contact us to learn more about our LC-MS services, and how we can assist you in your specific project.