Inflammation

Inflammatory Biomarker Detection

How to

Measure Inflammation

BioXpedia offers bioanalytical service for profiling of inflammatory markers on RNA, miRNA and protein level. Our laboratory analyses support projects from large-scale biomarker discovery to low-plex and single-assay quantification.

Inflammatory processes are involved in a wealth of diseases and pathological conditions, thus there is an enormous clinical interest in specific and sensitive analytical methods to quantify cytokines and chemokines.

 

Bioanalytical Technologies to Investigate Inflammatory Markers

 

Immuno-PCR from Olink Proteomics

  • Panel of 92 proteins associated to e.g. inflammation, immune-response, immuno-oncology

Multiplex immuno-assay from Meso Scale Discovery®

  • Quantification of proteins associated to proinflammatory processes, immunology, neuro-inflammation, immunogenecity

Digital barcode detection from NanoString Technologies

  • Expression profile of 200-770 genes associated to inflammation, immuno-oncology, immunology

Real-time quantitative PCR from Fluidigm Biomark

  • Flexible platform for gene expression, SNP genotyping and miRNA profiling, where you select the specimens and assays that you would like to measure.

What is

Inflammation

Inflammation is the primary response of the immune system against infection and foreign substances such as bacteria and viruses. When inflammation occurs cytokines from the white blood cells are released into the blood or the affected tissues to protect and heal the body.

Inflammation is a biological process of key importance for biomedical research. Understanding signalling processes of the immune system and how a disease or a proposed therapy modulates pathways of the immune response can provide important information for understanding disease pathology and provide new guidelines for diagnostics. Additionally, knowledge of inflammatory responses aids drug discovery and development.

 

Inflammatory Diseases

Chronic inflammation is known to be associated with a variety of diseases including rheumatoid arthritis, inflammatory bowel disease (IBD), dermatological diseases etc. However, it is becoming increasingly clear that chronic low-level inflammation may play an important role in a wide range of other diseases. The inflammatory processes are now found to be associated to many other types of pathologies such as multiple cardiovascular and neurological diseases, diabetes and several types of cancer.

What are cytokines and chemokines?

Cytokines and chemokines are small signalling proteins secreted primarily by immune cells. Their main function is to coordinate cell growth, proliferation, and differentiation. Cytokines and their receptors participate in a diverse array of functions including innate and adaptive immunity, inflammation, immune cell differentiation, angiogenesis, tumorigenesis, development, neurobiology, and viral pathogenesis. Dysregulation of cytokine expression is a cause of immunological and inflammatory diseases, as well as other disease conditions. Many different cell types secrete chemokines, most often to attract immune cells to the site of infection or injury during innate and adaptive immune responses.